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Guide to PDRN Injections: Comparing the 6 Best Polynucleotide Skin Boosters
In the rapidly evolving world of aesthetic medicine, the pursuit of truly regenerative, cell-level treatments has highlighted the importance of Polynucleotides (PN) and, specifically, Polydeoxyribonucleotides (PDRN). Moving beyond simple fillers that merely add volume, practitioners and patients are now seeking solutions that encourage the skin to heal, repair, and rejuvenate itself. PDRN injections, often derived from purified salmon DNA fragments (a safe and sterile process), are the biological signaling molecules that unlock this restorative potential.
Unlike traditional dermal fillers, PDRN acts as a powerful bio-stimulator. It doesn’t just mask the signs of aging; it targets the core mechanisms of skin degradation at a cellular level. PDRN binds to cell receptors, primarily stimulating the activity of fibroblasts—the cells responsible for producing crucial structural proteins like collagen and elastin. Furthermore, it directly supports cellular DNA repair, accelerates tissue healing, and provides notable anti-inflammatory and antioxidant benefits. This mechanism leads to significant improvements in skin texture, elasticity, hydration, and a noticeable reduction in the appearance of fine lines, scars, and sun damage. The six professional products listed here, including the core **Rejuran** variants and their primary competitors, represent the pinnacle of PDRN technology, offering specific concentrations and viscosities tailored for precise treatment goals.
🔬 Quality Criteria for a Professional PDRN Product
Selecting a high-quality injectable PDRN is critical for clinical safety and efficacy. The key factors that distinguish a premium product include:
- Source and Purity of Polynucleotides: The gold standard is PDRN extracted from pharmaceutical-grade salmon DNA, which must be highly purified to ensure sterility and non-allergenic properties. The concentration (e.g., 1%, 2% PN) and molecular weight define the intensity and focus of the biological effect.
- Viscosity and Molecular Weight: Products like **Ami Eyes** and **Rejuran I** use low viscosity for delicate areas (under the eyes), while **Rejuran S** uses high viscosity to act as a bio-stimulatory “filler” for fibrotic scars.
- Complementary Components: The inclusion of synergistic ingredients like Hyaluronic Acid (HA) and Lidocaine (as found in Rejuran HB Plus) is a hallmark of an advanced formulation, enhancing both hydration and patient comfort.
- Clinical Documentation and Approvals: Professional-grade products must be supported by robust clinical trials and possess the necessary regulatory approvals (like CE) to validate their safety and efficacy as injectable bio-stimulators.
💰 Category 1: Targeted PDRN Injections and Hydrating Formulas (Specialized Use)
This category groups PDRN formulas engineered with specific viscosities and components to treat delicate anatomical areas (eyes) or challenging skin conditions (scars), alongside a solution that combines regeneration with immediate hydration for superior comfort.
| Feature | Product 1: Ami Eyes | Product 2: Rejuran I (Eye) | Product 3: Rejuran S (Scar) | Product 4: Rejuran HB Plus |
|---|---|---|---|---|
| Product Image |  |  |  |  |
| Key Technical Feature | Low Viscosity PN: Specifically designed for eyelids and eye contour, minimizing the risk of lumps. | Thin PN (1%): Extremely fluid formula, ideal for thin and periorbital skin. The most famous for the eyes. | High Viscosity PN: Dense gel to physically lift and stimulate the repair of atrophic scars. | PN + HA + Lidocaine: Combination of regeneration + hydration + comfort, significantly reduces pain. |
| Primary Indications | Eye rejuvenation, dark circles, crow’s feet, and periorbital texture issues. | Deep dark circles, fine lines, periorbital and perioral laxity. | Atrophic acne scars, surgical scars, pitting, and skin depressions. | Dry/sensitive skin, fine lines, texture improvement with immediate hydration. |
| Average Professional Price* | $130 – $180 USD (per 2ml syringe) | $150 – $220 USD (per 1ml syringe) | $200 – $300 USD (per 1ml syringe) | $180 – $250 USD (per 2ml syringe) |
| User Rating (Avg. Pro Review) | 4.5/5.0 | 4.7/5.0 | 4.8/5.0 | 4.6/5.0 |
| Action | ORDER NOW | ORDER NOW | ORDER NOW | ORDER NOW |
*Note: Prices are estimates for professional bulk purchase and may vary based on supplier, region, and quantity.
💡 Category 1 Final Verdict:
For maximum structural specialization, **Rejuran S** is unmatched in scar treatment. For the eye contour, both **Rejuran I** and **Ami Eyes** are excellent low-viscosity options, with Rejuran I having more historical clinical validation. **Rejuran HB Plus** is the optimal choice when effective regeneration must be paired with maximum patient comfort due to the inclusion of Lidocaine and HA.
💎 Category 2: Flagship and All-in-One PDRN Injections (Total Regeneration)
This category includes the flagship PDRN products designed for comprehensive facial treatment, delivering overall skin rejuvenation, strengthening the skin barrier, and improving elasticity and hydration across a broad area. These are the workhorses of any advanced PDRN protocol.
| Feature | Product 5: Rejuran Healer (Flagship) | Product 6: Plinest (Standard) |
|---|---|---|
| Product Image |  |  |
| Key Technical Feature | High 2% PN Concentration: The original, high-purity PN formula for maximal collagen and elastin synthesis. | High Molecular Weight PN (HMW): Promotes enhanced tissue anchoring and prolonged tissue stimulation over time. |
| Indications | Full-face rejuvenation, texture issues, large pores, fine lines, general skin strengthening, anti-aging. | Overall firmness, elasticity, deep hydration, anti-aging on the face, neck, and hands. |
| Average Professional Price* | $250 – $350 USD (per 2x2cc pack) | $220 – $300 USD (per 2ml syringe) |
| User Rating (Avg. Pro Review) | 4.9/5.0 | 4.7/5.0 |
| Action | ORDER NOW | ORDER NOW |
💡 Category 2 Final Verdict:
The **Rejuran Healer** remains the undisputed flagship for comprehensive facial rejuvenation. Its high 2% PN concentration provides maximum cellular repair, making it the highest-performance product for stimulating collagen, shrinking pores, and restoring skin integrity across the entire face. It is the gold standard for aggressive regenerative effects.
⭐ Individual Product Deep Dives
1. Ami Eyes (Specialized Periorbital Solution)
Review: Ami Eyes has quickly emerged as a major competitor to Rejuran I, having been specifically developed for the rejuvenation of the delicate periorbital area. This product utilizes low-viscosity Polynucleotides (PN), a key feature for use in an area with thin skin where the risk of nodule formation or the Tyndall effect must be completely avoided. Its formulation is optimized to spread evenly within the thin dermis, working to strengthen the skin structure, improve elasticity, and ultimately reduce the appearance of fine lines, wrinkles, and especially dark circles. Ami Eyes’ mechanism focuses on the targeted stimulation of fibroblasts, which in turn boosts collagen and elastin production. Many professionals appreciate its easy handling profile and often more accessible cost compared to its direct Korean competitor, Rejuran I. It is the ideal choice for patients seeking significant brightness improvement, reduction of under-eye pigmentation, and a gentle lifting effect without resorting to dense filler. It is an excellent alternative that delivers professional and focused results for those specializing in eye contour treatment.
2. Rejuran I (Eye) (Ultra-Fluid PDRN for Periorbital Area)
Review: Rejuran ‘I’ is Rejuran’s specialist formulation, created precisely for the periorbital zone. The skin here is exceptionally thin and sensitive. Rejuran I excels due to its low concentration of Polynucleotides (typically 1%) suspended in an extremely fluid gel (low viscosity). This unique consistency is crucial, as it allows for smooth, uniform intradermal injection that prevents the temporary bumps or nodules that could occur with denser products. Its primary function is to stimulate collagen and elastin production specifically in this thin dermis, effectively treating fine lines (crow’s feet), skin laxity, and improving the appearance of dark circles by strengthening the skin structure. Despite its efficacy, strong topical anesthesia is necessary due to the area’s sensitivity. However, the less-viscous nature of the product makes the procedure generally more tolerable than the thicker Rejuran Healer. Rejuran I is the essential choice for practitioners looking for a targeted, validated solution for eye rejuvenation, providing results that gradually enhance skin quality and the freshness of the gaze.
3. Rejuran S (Scar) (High-Viscosity Scar Repair)
Review: Rejuran ‘S’ is a high-viscosity product uniquely formulated for the treatment of depressed, atrophic scars, particularly those resulting from severe acne (boxcar, rolling scars) or trauma. The ‘S’ stands for Scar, and its density is its core strength. The formulation is intentionally much thicker than Rejuran Healer or I, behaving like a semi-liquid bio-filler. It is designed to be injected directly beneath the scar tissue to achieve a dual effect: **physical lifting** and **intensive regeneration**. The thickness of the gel aids in breaking up the fibrotic bands that pull the scar downward (a form of subcision) while the highly concentrated PN delivers a robust, localized biological signal. This encourages the aggressive production of new collagen and elastin deep within the damaged dermal structure, progressively remodeling and filling the depression. Rejuran S is not for general mesotherapy but is a targeted treatment tool. Due to its high viscosity, injection is often performed with a cannula for precise and safe placement, and patients should be prepared for potential temporary swelling or bumps. For clinics specializing in acne scar management, Rejuran S is an indispensable, clinically validated tool that delivers profound, lasting structural correction.
4. Rejuran HB Plus (PN, Hyaluronic Acid, and Lidocaine)
Review: Rejuran HB Plus (where ‘HB’ stands for Hydro Booster) is Rejuran’s answer to the demand for a more comfortable and immediately hydrating PDRN treatment. This formulation is an excellent synergistic blend that combines Polynucleotides (PN) for regeneration, non-cross-linked Hyaluronic Acid (HA) for deep hydration, and, crucially, Lidocaine to minimize injection pain. The HA component provides an immediate plumping effect and a visible “glow,” reducing fine lines caused by dehydration, while the PN works over time for structural repair. The Lidocaine addresses the main patient complaint about Rejuran Healer treatments (pain), making HB Plus ideal for patients with a low pain threshold or those new to injectable bio-stimulators. Although it has a slightly lower pure PN concentration than Rejuran Healer (the formulation is diluted to accommodate HA and Lidocaine), it still offers a powerful regenerative effect coupled with superior hydration and a significantly better patient experience. It is a versatile “all-in-one” solution that bridges the gap between traditional HA skinboosters and pure PDRN bio-stimulators.
5. Rejuran Healer (Flagship All-Rounder)
Review: Rejuran Healer is the foundational product of the Rejuran line and is globally recognized as the gold standard for comprehensive, full-face cellular rejuvenation. It features a robust 2% PN concentration—one of the highest available for general use—and a medium viscosity. This viscosity is carefully balanced to ensure maximum fibroblast stimulation for collagen and elastin production, while remaining manageable for full-face micro-injection techniques. The “Healer” moniker is well-deserved, as it excels at repairing skin damage, strengthening the epidermal barrier, and visibly reducing the appearance of large pores and fine lines. Its deep regenerative mechanism provides genuine, long-term improvement in skin quality and density, leading to the highly sought-after “glass skin” effect. However, due to its high concentration and viscosity, Rejuran Healer injections are often perceived as painful, necessitating robust topical anesthetic. Patients should also be prepared for a few days of potential small bumps (papules) at the injection sites as the product is absorbed and initiates the healing process. Despite these minor trade-offs, its extensive clinical backing and powerful, visible, long-lasting results in global skin health secure its position as the premier flagship PDRN booster for any professional seeking maximum regenerative performance across the entire face.
6. Plinest (Standard) (High Molecular Weight PN)
Review: Plinest Standard, from the Italian Mastelli aesthetic line, serves as a powerful full-face biorevitalizer. Its core formulation utilizes High Molecular Weight (HMW) Polynucleotides. This HMW structure provides a distinct advantage: a longer retention time in the dermis and an enhanced anchoring effect. This promotes a sustained and prolonged signaling process to the fibroblasts, leading to slower but more sustained collagen synthesis and tissue firming compared to lower molecular weight products. Plinest Standard focuses on improving overall skin tone, elasticity, and combating moderate signs of aging across the face, neck, and hands. Its injection profile is smooth and less viscous than Rejuran Healer, generally resulting in less immediate discomfort and a lower chance of prolonged papule formation. The product is highly regarded for its ability to deliver noticeable improvement in skin firmness and density, particularly in areas prone to laxity like the neck and jowls. As a standalone anti-aging treatment, Plinest Standard is a reliable alternative to the Korean Rejuran line, particularly favored in European and global markets for its excellent purity standards and predictable performance. It is an ideal choice for patients who prioritize reduced downtime and a gradual, yet profound, firming effect.
Conclusion: Selecting the Right PDRN for Your Practice
The updated selection of professional PDRN injections underscores the importance of specialization in the aesthetic industry. A modern practice requires more than a single “all-rounder” product. It needs a tailored approach utilizing products like Rejuran I and Ami Eyes for delicate areas, Rejuran S for targeted scar correction, and the high-performance Rejuran Healer or the European standard Plinest for comprehensive full-face regeneration. The inclusion of composite formulations like Rejuran HB Plus demonstrates the ongoing innovation to maximize patient comfort and dual-action results.
By understanding the critical differences in viscosity (low for eyes, high for scars) and composition (pure PN vs. PN+HA), practitioners can customize protocols that maximize efficacy, minimize downtime, and deliver the specific, high-quality results their patients demand. Integrating these top-tier PDRN boosters will ensure your clinic remains at the forefront of regenerative aesthetic medicine.
The Science of Regeneration: Clinical Evidence for PDRN Efficacy
The utilization of Polydeoxyribonucleotide (PDRN) in regenerative aesthetics is supported by a robust body of clinical research. Understanding the molecular pathways explains why PDRN brands like Rejuran and Placentex have become gold standards for skin repair and anti-aging.
1. Adenosine A2A Receptor Activation
The primary mechanism of PDRN involves the selective activation of the Adenosine A2A receptors. According to a 2025 study published in PMC (ID: 12473307), this activation triggers a “wound healing cascade” even in non-wounded aging skin. This process downregulates chronic low-grade inflammation (inflammaging) and significantly stimulates fibroblast proliferation, the cells responsible for structural integrity.
2. Stimulation of Endogenous Collagen & Elastin
Clinical data from MDPI (2025) indicates that PDRN treatment leads to a marked upregulation of COL1A1 and COL3A1 genes. In vivo trials have demonstrated that Type I and Type III collagen levels can increase by 1.3x to 3x compared to placebo, leading to measurable improvements in skin density and a significant reduction in the depth of atrophic acne scars.
3. Mitochondrial Protection & Skin Longevity
Cutting-edge research released in late 2025 (PMC12731532) has highlighted PDRN’s role in mitochondrial maintenance. By protecting mitochondrial membrane polarization and optimizing the ATP/ADP ratio, PDRN attenuates oxidative stress induced by UV-A and environmental pollutants. This makes it not only a corrective tool for scars but a preventative “longevity” active for the skin barrier.
4. Results in Scar Remodeling
A 2024 multicenter clinical trial (Taylor & Francis) evaluated PDRN-based treatments for various facial scars. The study reported a 92% faster repair rate in treated tissues compared to control groups, with a substantial reduction in texture irregularity and post-inflammatory discoloration after only two sessions.
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