Understanding PDRN: Polynucleotides and Cellular Regeneration

PDRN is a low-molecular-weight fragmented DNA molecule, extracted from salmon (Salmonidae), boasting a structural composition very similar to human DNA. This similarity allows PDRN to be easily recognized and utilized by cells for repair and regeneration.

Distinctive Characteristics of Clinical PDRN/PN Products:

• PN (Polynucleotides) vs. PDRN (Polydeoxyribonucleotide): PN is essentially a longer, more complex chain of PDRN, often used in more advanced injectable products (like Rejuran) for a deeper regenerative effect. PDRN is the shorter form, primarily used in injectable formulations for mesotherapy.
• Biological Action: PDRN acts as a “building block” for repairing damaged DNA and as a potent agonist of the adenosine A2A receptor, which triggers an intense anti-inflammatory and healing response.
• Purity and Sterility: High-quality injectable products must guarantee maximum purity, isolation from foreign proteins, and sterilization to prevent adverse reactions. Professional brands like Rejuran and Placentex are subject to strict pharmaceutical standards.
• Indications: Injectable PN and PDRN are indicated for the treatment of scars (particularly atrophic acne scars), deep wrinkles, loss of elasticity, enlarged pores, and for general rejuvenation of the eye contour, neck, and décolleté.

These injections offer an intensive, regenerative approach that targets the biological cause of aging and skin damage, ensuring structural and long-term results.

💎 Comparison of the 3 Best Professional PDRN/PN Solutions (Injectables)

These products represent the clinical standard for skin tissue regeneration. Note: These are medical-grade products and must be administered by authorized healthcare professionals.

Professional PDRN/PN Solutions Comparison

Feature/Product	Rejuran Healer (PN)	Placentex (DNA Sodium Salt)	Rejuran I (PN for Eyes)
Product Image
Key Ingredient	Polynucleotides (PN)	DNA Sodium Salt (PDRN)	Polynucleotides (PN) less viscous
Treatment Goal	Deep rejuvenation, acne scars, elasticity.	Tissue repair, post-operative healing, anti-inflammatory.	Fine lines, dark circles, eye contour rejuvenation.
Price (per treatment, est.)	High (>$300 per vial)	Medium-High (>$100 per vial)	High (>$250 per vial)
Rating (5-star scale)	★★★★★ (4.9/5)	★★★★☆ (4.5/5)	★★★★☆ (4.7/5)
Information Link	Order Now	Order Now	Order Now
Professional Verdict: Rejuran Healer is the gold standard for full-face PN injection. Rejuran I is the specific and safer choice for the sensitive eye area. Placentex offers a general pharmaceutical PDRN focused on repair.

Review: Rejuran Healer (PN)

Rejuran Healer is the most globally recognized PN (Polynucleotide) product, often referred to as “injectable Salmon DNA” for its ability to restore skin to a younger state. Its potency lies in the use of long-chain PN, which acts as a scaffold within the dermis. Once injected (usually via micro-papules), the PN in Rejuran intensely stimulates the proliferation of fibroblasts, which are the cells responsible for collagen and elastin production.

Rejuran Healer treatments are renowned for significant improvements in skin elasticity, reduction of fine wrinkles, pore tightening, and, in particular, the correction of atrophic acne scars. For those seeking a biological rejuvenation solution with top-tier clinical support, Rejuran Healer represents the definitive investment in the injectable PN category.

Review: Placentex (DNA Sodium Salt)

Placentex (often distributed by Mastelli) is a historical pharmaceutical product based on PDRN (DNA Sodium Salt) with a long tradition of use in medicine for wound healing and tissue regeneration. Its high-purity PDRN formulation makes it an excellent choice for mesotherapy and post-procedural use. Its action focuses on directly supplying DNA building blocks, promoting cellular repair and reducing inflammation.

This product is particularly valued for its effectiveness in improving skin healing after aggressive procedures like deep chemical peels, lasers, or microneedling. Furthermore, when used as part of a mesotherapy cocktail, Placentex helps improve hydration and gives the skin a healthier, plumper appearance. As an established pharmaceutical product, it boasts a high safety and reliability profile.

Review: Rejuran I (PN for Eyes)

Rejuran I is specifically formulated for the delicate and sensitive eye area. While sharing the same active ingredient (Polynucleotides/PN) as the Healer, its key difference lies in its lower viscosity. This reduced viscosity is crucial to prevent the formation of lumps or papules that could be noticeable under the thin skin of the eyes, a potential side effect with the standard, more viscous Healer.

Its targeted action is excellent for treating fine lines, crow’s feet, loss of elasticity, and dark circles due to thinning skin. By stimulating collagen in the sub-dermal layer of the eye contour, Rejuran I safely provides a regenerative boost, leading to thicker, brighter, and firmer skin in this critical area, without the risk associated with highly viscous fillers.

Pros and Cons Summary (Professional Options)

Conclusion: Choosing Your Professional PDRN Solution

PDRN offers a powerful path towards cellular rejuvenation and tissue repair. The choice of the most suitable professional solution will depend on the primary clinical objective:

• For Deep and Structural Tissue Regeneration (Full Face), injectable PN like Rejuran Healer is unmatched. It is the most effective solution for scars, enlarged pores, and severe aging.
• For Targeted Regeneration of the Eye Contour, Rejuran I is the product of choice, due to its low viscosity and safety profile for the periorbital area.
• For Repair, Healing, and Anti-inflammatory Support, Placentex provides a consolidated pharmaceutical-grade PDRN.

Warning: all these products are medical-grade and must be administered exclusively by an authorized healthcare professional. The regular use of injectable PDRN provides an excellent foundation for more resilient, healthier, and visibly regenerated skin.